Filling Scheme of Spray for External Use on Skin

Topical drugs play a very important role in the treatment of skin diseases. For example, the products covered include the treatment of musculoskeletal pain, promoting blood circulation and dispersing blood stasis, reducing swelling and pain, skin antibacterial agents, relieving itching, allergies, skin burns, infections, and dermatitis, all of which are common household care medications.

Spray means that the solution containing medicine is filled in a special device, and the solution is released as a mist with the help of pressure. Its advantages: use spray instead of coating, simple and clean, less irritating to the skin, especially suitable for large areas of skin lesions; Good preservation and high stability, as the drug is stored in a closed container isolated from the air, the chance of oxidation is reduced and it is not easily contaminated by external bacteria; When applied topically, the drug is evenly distributed, has a large contact area with the affected area, has good permeability to the wound, can improve efficacy, and has less drug loss.

At present, the domestic external skin sprays are mostly packaged in plastic bottles and manual pumps. However, with the continuous improvement of the technical level of pharmaceutical preparations and the continuous listing of new drugs, a variety of new product sprays are increasing. Aerosols are widely used in the pharmaceutical industry. New packaging forms have emerged. Aerosol can packaging (aluminum cans or iron cans) uses the pressure of the propellant to spray the solution. The atomization effect is better and the user experience is stronger. It is gradually applied in China.

Production process of topical skin spray

The commonly used solvents for the preparation of topical skin sprays are ethanol and water. However, due to the different nature of the active ingredients of drugs, specific pharmaceutical solvents and other additives must be selected to prepare solution type sprays, lotion type sprays or suspension type sprays. Appropriate excipients can make the drugs play a good role.

If the spray without propellant gas is made, it is composed of a manual pump (or valve system) and a bottle body. The valve system can be a quantitative valve system or a non quantitative valve system. The basic composition of the valve system is the basic pump, screw cap, immersion tube, washer, push button, spray head, integrated atomizer and protective cover. The process flow is: raw material production - bottle sorting - filling - valve installation - cap rolling - labeling - coding - packaging.

If it is made into an aerosol containing a propellant, it consists of an aerosol can (iron or aluminum can), a valve, propellant gas, a nozzle, an outer cover, etc. A valve is a set of valves consisting of a valve cup, a valve chamber, a valve stem, an inner gasket, an outer gasket, a spring, and a suction tube and button. Commonly used propellant gases include liquefied petroleum gas (propane, butane), dimethyl ether, nitrogen, carbon dioxide, Freon, tetrafluoroethane, etc. Choose the appropriate propellant gas based on the characteristics of the product. The process flow is as follows: raw material production - bottle sorting - liquid filling - valve installation - sealing - filling with propellant gas - weighing - water inspection - nozzle fastening - outer cover fastening - packaging, etc.